HPLC Method Validation For Pharmaceuticals: A Quick Review

The validation of HPLC methods is necessary to determine the suitability of the procedure for the intended use. The high-performance liquid chromatography or HPLC analysis is a chromatographic procedure which utilizes small particle columns to pump mobile phases at high pressure. The separation of the corresponding component is dependent on the interaction extent between the stationary phase and the solute component. The stationary phase components that have low affinity elute first.

Source URL: https://vigyaa.com/@jyotichauhan.jy-1417/hplc-method-validation-for-pharmaceuticals-a-quick-review-1f0303ae/

Explain the Importance of Pharmacokinetic (PK) Studies in Drug Discovery and Development

Pharmacokinetic is a pharmaceutical procedure which gives the basic influence and time course of the sample drug compound. Being an essential factor of drug discovery and development, the PK studies assess the biological properties of the given drug compound for its intended use. Various pharmacokinetic properties are evaluated during PK studies, such as absorption, distribution, metabolism, and excretion.

Source URL: http://www.whatiswhatis.com/importance-pharmacokinetic-pk-studies-drug-discovery-and-development/

Ultimate Guide to Analytical Method Validation for Drug Development and Testing

Method validation is the process utilized by scientists and researchers to maintain accuracy and reliability for method development in the field of drug discovery and development. Test method validation such as analytical procedure is an essential aspect of the final results in the development of pharmaceuticals. Scientists are required to use the right techniques that are viable in correlation with performance quality. The consequent analytical method needs to be assessed to detect pharmaceutical quality.

 

 


Source URL: http://cirandas.net/priyankagarg/top-5-soldering-stations-for-hobbyists/ultimate-guide-to-analytical-method-validation-for-drug-development-and-testing

Significance of HPLC Method Development, Validation, and Sample Analysis

High-performance liquid chromatography (HPLC) is the part of method development which may seem complex because of the high number of processes. protocols, parameters and equipment for successful completion of the process.However, scientists working in laboratories where the processes are created will follow straightforward and planned steps to ensure the results are dependable and usable by the pharmaceutical industry.

Source URL: http://www.sunspirestudios.com/significance-of-hplc-method-development-validation-and-sample-analysis/

How can Bioanalysis Accelerate Drug Development

The drug discovery and development is a crucial project that can take up to 10 years for market release and approximately USD 1 billion for completion. The process involves generating various drug candidates and assessing all the underlying properties of these compound so that one NCE (Novel Chemical Entity) can be developed. The NCE is considered safe for administration by the humans for the treatment of intended disease or illness. Bioanalysis plays a major role during these processes of drug discovery and development.

Source URL - https://www.bloglovin.com/@nebiolab/how-can-bioanalysis-accelerate-drug-development

Analytical Testing Laboratory Services for Drug R&D

An analytical services laboratory helps drug developers and manufacturers through different phases of drug compound development from pharmacokinetics and toxicokinetic studies to analytical assay development. However, they vary in terms of their industry, specialties, techniques, and instruments used. Hence, there are several categories of analytical services offered by drug testing and analysis labs. Let’s explore these services.

Source URL: https://dailygram.com/index.php/blog/546188/analytical-testing-laboratory-services-for-drug-r-d/

How does Bioavailability affect Drug Efficacy?

The most interesting aspect of medicinal drugs is that they can be administered through different routes by using varied delivery techniques. The common routes of drug administration include oral, inhalational, intramuscular, intravenous, sublingual, topical, and per-rectal. For a single route, there may be different delivery systems. For instance, the same drug can be administered orally in the form of tablets, syrups or capsules. After entering the human body, the drug has to reach its site of action to generate the therapeutic response.

Source URL: https://articles.abilogic.com/376612/how-does-bioavailability-affect-drug.html

An Overview of Cytotoxicity Assay During Drug Development

Cytotoxicity, as the name suggests, is the toxicity of the cells. When the cells are treated with cytotoxic compounds, it may lead to cell necrosis - leading to loss of membrane integrity, and the result is rapid death caused by cell lysis. These cells can stop growing and dividing, or the cells can activate a genetic program leading to controlled death.

The absorption of harmful chemicals causes cytotoxicity – the chemicals can kill cancer cells but have the potential to destroy the healthy cells also. In drug development, studying cytotoxicity is necessary because cytotoxic drugs are necessary for treating critical diseases. The drugs contain chemicals which are toxic to cells, preventing their replication or growth and are effective to control diseases such as cancer.

Source URL: https://www.apsense.com/article/an-overview-of-cytotoxicity-assay-during-drug-development.html